Re:Pair Genomics
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Re:Pair Genomics

Compact synthetic regulatory elements for gene therapy. ML-designed, synthesis-ready, delivered in days.

Re:Pair Genomics

SpinUP, 3359 Mississauga Rd

Mississauga, Ontario L5L 1C6, Canada

info@repairgenomics.com

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© 2026 Re:Pair Genomics Inc.

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Gene Therapy Infrastructure

MakingTissue-TargetingEasier.

Our machine-learning algorithm designs compact, synthetic regulatory elements (promoters and enhancers) for gene therapies within a day, cutting design time from months to hours.

Partner With UsSee How It Works

Supported by

NVIDIA
University of Toronto
EGG
Health Innovation Hub
IP Ontario
Tech Alliance
Med by Design
Prime
Mitacs
Innovation Factory
BioTalent
Tech@RBC
Riipen Level UP
Synapse
UofT Entrepreneurship
Desjardins
BioHubNet
UTEST
AWS Activate
SpinUP
Centre for Aging + Brain Health Innovation
OBIO
NVIDIA
University of Toronto
EGG
Health Innovation Hub
IP Ontario
Tech Alliance
Med by Design
Prime
Mitacs
Innovation Factory
BioTalent
Tech@RBC
Riipen Level UP
Synapse
UofT Entrepreneurship
Desjardins
BioHubNet
UTEST
AWS Activate
SpinUP
Centre for Aging + Brain Health Innovation
OBIO
Why Re:Pair

Customizedfortheresearcherswhoneeditmost.

01

Targeting Specific Cell Types

Therapies fail when promoters are generic. We design regulatory DNA tuned to the exact cell types you care about—neurons, astrocytes, microglia, and more—so your cargo expresses where it should, not everywhere it should not.

Cell Type SpecificCompact SizeHigh Strength
Re:Pair team members collaborating in the lab on cell-targeting research.

02

Transfecting Cells with DNA Plasmids

Once targets are clear, we help you move from sequence to transfection-ready plasmids. Our workflow keeps iteration tight so your lab spends less time cloning and more time validating biology.

  • Sequence-optimized regulatory modules
  • Plasmid maps and synthesis-ready formats
  • Iteration loops aligned to your assay schedule
Team conducting DNA plasmid and transfection workflow activities in the lab.
03

Proof at program speed

Ranked designsready in a day.

Go from structured input to ranked designs, rationale, and synthesis-ready files in a day. Allowing your program timelines to compress without cutting specificity.

1

Day turnaround

< 14%

Current gene therapy success rate

22+

Institutional partners

Platform architecture

One synchronized output—four engineering constraints.

Cell-type specificity

Regulatory DNA tuned to the tissues and cell populations you specify—so expression lands where your program needs it, not everywhere else.

High activity

Designs emphasize robust, controllable expression aligned to your therapeutic window and the readouts your team will trust.

Payload independence

Modular elements that slot into diverse viral and non-viral backbones without forcing a ground-up redesign of your construct architecture.

Small size

Compact promoters and enhancers that preserve cargo capacity and stay friendly to synthesis and delivery constraints.

Our Advantage

Speed. Accuracy. Flexibility.

Speed

1 day

versus months of manual promoter engineering and literature triage.

  1. Design→
  2. Ranked candidates→
  3. Synthesis-ready outputs

Accuracy

Models are trained to respect tissue context and manufacturing constraints—not just maximize in silico scores.

Transparency

We provide validation data for the patented promoters.

Highlight

Every design is traceable: inputs, constraints, and ranking rationale ship with the sequences.

Flexibility

AAV, LV, non-viral contexts; rodent and human; disease models and screens—one workflow adapts to your program.

Delivery & models

AAVLentivirusDNA onlyHumanMousePrimary cellsiPSC-derivedIn vivoEx vivo
The Process

HowOurAIAlgorithmWorks

See how our platform takes you from login to ranked promoter candidates in minutes.

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Join academia and companies partnering with us.

Limited pilot slots for qualified academic labs and industry teams. Tell us your target profile and we will scope a trial that fits your timeline.

Contact Us